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The Simpsons’ twenty-second season began airing on Fox on September 26, 2010 and ended on May 22, 2011. The Simpsons was renewed for at least two additional seasons during the twentieth season leading up to this season. The cast is currently signed through the 25th season. On November 11, 2010, the series was renewed for a 23rd season by Fox with 22 episodes.
- 22 - 1Elementary School Musical Sep. 26, 2010
- 22 - 2Loan-a-Lisa Oct. 03, 2010
- 22 - 3MoneyBART Oct. 10, 2010
- 22 - 4Treehouse of Horror XXI Nov. 07, 2010
- 22 - 5Lisa Simpson, This Isn't Your Life Nov. 14, 2010
- 22 - 6The Fool Monty Nov. 21, 2010
- 22 - 7How Munched is that Birdie in the Window? Nov. 28, 2010
- 22 - 8The Fight Before Christmas Dec. 05, 2010
- 22 - 9Donnie Fatso Dec. 12, 2010
- 22 - 10Moms I'd Like to Forget Jan. 09, 2011
- 22 - 11Flaming Moe Jan. 16, 2011
- 22 - 12Homer the Father Jan. 23, 2011
- 22 - 13The Blue and the Gray Feb. 13, 2011
- 22 - 14Angry Dad: The Movie Feb. 20, 2011
- 22 - 15The Scorpion's Tale Mar. 06, 2011
- 22 - 16A Midsummer's Nice Dream Mar. 13, 2011
- 22 - 17Love Is a Many Strangled Thing Mar. 27, 2011
- 22 - 18The Great Simpsina Apr. 10, 2011
- 22 - 19The Real Housewives of Fat Tony May. 01, 2011
- 22 - 20Homer Scissorhands May. 08, 2011
- 22 - 21500 Keys May. 15, 2011
- 22 - 22The Ned-Liest Catch May. 22, 2011